Methoxybenzoic acids and derivatives
Medchemexpress LLC Ro 08-2750 | 37854-59-4 | 98.01% | 270.24 | 10 MG
Ro 08-2750 is a non-peptide and reversible nerve growth factor (NGF) inhibitor that binds to NGF with an IC50 of approximately 1 μM. It selectively inhibits NGF binding to p75NTR over TRKA. Ro 08-2750 is also a selective MSI RNA-binding activity inhibitor, with an IC50 of 2.7 μM.
- Binds to the NGF dimer, potentially inducing a conformational change that prevents NGF from binding to p75NTR.
- Completely rescues cells from NGF-induced SK-N-MC 103 cell death at 10 nM.
- Increases differentiation and apoptosis in myeloid leukemia cells at 5-10 μM (8 hours).
- Inhibits survival of human AML lines and patient cells.
- Inhibits MSI2 RNA-binding and alters MSI2 gene signature.
- Inhibits leukemogenesis in a myeloid leukemia model in vivo at 13.75 mg/kg (i.p.).
- Reduces c-MYC levels and disease burden in a myeloid leukemia model.
eMolecules 2-((FMOC)AMINO)-5-(2-METHOXYETHOXY)BENZOIC ACID | 1065075-74-2 | MFCD11100930 | 1g
AstaTech | 2-((FMOC)AMINO)-5-(2-METHOXYETHOXY)BENZOIC ACID | 1g | 112532226 | AR3326 | 95.000 | 1065075-74-2 | MFCD11100930 | 433.460 | C25H23NO6
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Medchemexpress LLC Methoxy-x04 | 863918-78-9 | MFCD25563254 | 98.5% | 344.4 g/mol | C23H20O3 | 25 MG
Methoxy-X04 is a blood-brain barrier-permeant fluorescent probe that selectively binds beta-pleated sheets in dense core amyloid β (Aβ) plaques. It is used for in vivo imaging and for histological staining of Aβ plaques, tangles, and cerebrovascular amyloid, and exhibits high affinity for Aβ fibrils.
- Blood-brain barrier permeant fluorescent probe.
- Selectively binds beta-pleated sheets in amyloid β plaques.
- Suitable for in vivo imaging and histological staining.
- High binding affinity for Aβ fibrils (Ki = 26.8 nM).
- High purity supply (>98% by HPLC).
Medchemexpress LLC Methyl isovanillate | 6702-50-7 | 182.18 | 1 ML
Methyl isovanillate is a secondary metabolite isolated from Vitex agnus-castus. It does not exhibit significant activity in the DPPH free radical scavenging experiment.
- Purity: 99.65%
- Molecular weight: 182.18
- Formula: C9H10O4
- Appearance: Solid
- CAS number: 6702-50-7
- Structure classification: Phenols, Monophenols
Apexbio Technology LLC Ro 08-2750 37854-59-4 1mg
Ro 08-2750 (CAS 37854-59-4) is a small molecule antagonist of nerve growth factor (NGF) that selectively inhibits NGF binding to the p75 neurotrophin receptor (p75NTR) over TrkA With an IC50 of 1 M for NGF binding Ro 08-2750 induces a conformational change in NGF preventing its interaction with p75NTR while sparing TrkA association at lower concentrations In vitro studies demonstrate that Ro 08-2750 modulates NGF-mediated signaling including suppression of NGF-induced apoptosis in SK-N-MC cells and enhancement of TrkA pathway activity in PC12 cells This compound serves as a valuable tool for investigating the distinct roles of p75NTR and TrkA in neuronal apoptosis differentiation and axonal growth
Medchemexpress LLC 3-ethoxy-3-oxopropanoic acid | 1071-46-1 | MFCD00020490 | >96.0% | 132.11 g/mol | C5H8O4 | 5g
3-Ethoxy-3-oxopropanoic acid is an endogenous metabolite 3-Ethoxy-3-oxopropanoic acid promotes plant growth[1]
Selleck Chemical LLC KN-93
KN-93 is a cell-permeable reversible and competitive inhibitor of Ca2 /calmodulin-dependent protein kinase II (CaMK-II) with Ki of 2 58 M at rabbit myocardial CaM kinase activity
Medchemexpress LLC (S)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride | 93601-86-6 | 99.99% | 255.78 | 10 G
(S)-5-Methoxy-N-propyl-1,2,3,4-tetrahydronaphthalen-2-amine hydrochloride is a chemical compound primarily used as a drug intermediate. It is essential for the synthesis of various active pharmaceutical compounds.
- Drug intermediate for synthesis of active compounds.
Apexbio Technology LLC 5-Methoxy-CTP(Synonyms: 5-Methoxycytidine triphosphate, 5-Methoxy-CTP, 5-MeO-CTP, 5-Methoxy Cytidine-5'-triphosphate), 10x100ul (100 mM).
5-Methoxy-CTP is a chemically modified cytidine triphosphate analog, characterized by a methoxy group substitution at position 5 of the cytosine ring. During in vitro transcription, it can be enzymatically incorporated into synthesized RNA, resulting in RNAs containing 5-methoxy-modified cytidine residues. This methoxy substitution influences RNA chemical properties, alters its structural characteristics, and enhances resistance against intracellular nucleolytic degradation. Consequently, 5-Methoxy-CTP is valuable for investigating RNA structural dynamics, RNA-protein interactions, and RNA functional roles, and it holds potential utility in RNA-based therapeutics, functional genomics research, and gene therapy approaches.